The pathogenesis of retinal dysplasia.

The term retinal dysplasia has been em­ ployed with two connotations in the ophthal­ mic literature. Its early usewas the more general, referring to abnormalities in the histogenesis of the developing retina. The term was used more restrictively by Reese and Blodi and Reese and Straatsma to desig­ nate a specific syndrome consisting of multi­ ple congenital anomalies, including bilateral ocular abnormalities, presenting a more or less typical histopathologic picture. The wide­ spread application of karyologic analysis during the past decade has made it clear that most of the cases of this syndrome described by Reese and coworkers' were probably re­ lated to a trisomy in the D group of chromo­ somes (13-15 trisomy).